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February 2019
A 56-year-old male with a subcutaneous mass
Contributors:
Karen E. Trevino MD
PGY3-Department of Pathology and Labortoey Medicine Residency
Indiana University School of Medicine
and
Ahmed K. Alomari, FEL, MD
Assistant Professor of Clinical Pathology & Laboratory Medicine
Indiana University School of Medicine
Clinical history: A 56-year-old male presented to his primary care physician with a slowly enlarging subcutaneous nodule on his upper arm. No changes to his overlying skin were seen and an excisional biopsy was performed.
Microscopic examination: The biopsy demonstrates a subcutaneous mass (Figure 1) consisting of sheets and cords of spindled to round cells in a fibrous, hyalinized stroma (Figures 2 and 3). The mass is well encapsulated with a partial rim of bone and fibrous capsule surrounding it (Figure 4). No significant atypia or mitotic activity is seen in either the spindled cells or the bone.
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Fig. 1
Figure 1. Subcutaneous mass
Fig 2.
Figure 2. Rounded cells in hyalinized background (10x)
Fig.3
Figure 3. Rounded and spindled cells (20x)
Fig 4.
Figure 4. Bony capsule (2x)